The Natick community has a long history of working collaboratively to address substance use. Since the 1980s, Natick has supported a series of community committees and coalitions made up of dedicated parents, school representatives, law enforcement, public health professionals, town leaders, and engaged community members working to prevent and reduce youth substance use in the community. Their collective efforts led to the Natick Together for Youth (NTY) Coalition obtaining the federal Drug-Free Communities (DFC) grant in 2011, a five-year grant that assists communities in building the readiness and infrastructure to tackle the most pressing substance use issues faced by youth. As the nationwide opioid crisis grew and the need for a more targeted response became more evident, NTY representatives worked closely with Natick town leaders to organize a task force focused specifically on the opioid epidemic. In September 2016, The Natick Board of Selectmen convened the Natick Opioid Task Force (OTF) to bring together municipal departments and local organizations to build a sustainable, coordinated, multidisciplinary system of support, education and treatment for those affected by this public health crisis. The collective efforts of NTY, the OTF and their partners included:
Making Naloxone (Narcan) available on every Natick Police and Fire Department vehicle and in every Natick Public School. The Natick Health Department also offers Naloxone training and distribution to any resident at no cost.